Christina Applegate has delivered one of the most memorable moments from the 75th Emmy Awards.

Presenting the Outstanding Supporting Actress in a Comedy Series award to Ayo Edebiri for her role in The Bear, Applegate received a heartfelt standing ovation from her peers.

Applegate, who lives with multiple sclerosis, playfully responded:  “You’re totally shaming me and my disability by standing up,” followed by a humorous remark, “Body not by Ozempic.”

A class act.

Christina Applegate poses before attending the 75th Emmy Awards.